I am hugely hooked on Beer School, a monthly-ish podcast you can get for free from the iTunes Store. Erika loaded a few of them on our 'pod for the long ride to and from NYC. The hosts, Motor and John, have a theme for each show and sample beer throughout each episode. Yes, they start to get a little off-topic as they drink, and it can be pretty funny. They're based in San Francisco and, from what I can gather, work in the IT business. Motor, who sometimes punctuates the dialogue with belches, seems like the kind of guy who's ripped his shirt off at an outdoor party after a few brews more than once in his life.
Some highlights include the guys drinking skunked Landshark beer ("Leftovers") and Motor guzzling that horrific Budweiser/clamato 22 oz thing — and loving it ("Weird"). But most of the time they just sample quality brews from around the world. If you love good beer or are curious about the whole craft beer movement, I encourage you to give it a listen.